Neurologist-recommended Petadolex contains the patented extract of butterbur that supports healthy blood vessel tone in the brain, as well as normal blood flow in the brain. Petadolex is standardized to contain 15% of butterbur's key ingredient, petasin. It's also guaranteed to be pyrrolizidine alkaloid PA free, so you can use it with confidence. PA's are toxic compounds that can harm the liver. Studies demonstrate patented Petadolex is safe and well tolerated.