Pyroglutamate is an amino acid present in large amounts in the human brain, cerebrospinal fluid, and blood. Pyroglutamate is known to have a number of remarkable cognitive-enhancing effects. Pyroglutamate has shown to cross the blood-brain barrier and stimulate memory, focus and cognitive functions. Pyroglutamate has also been shown to be effective in alcohol-induced memory deficits in humans and, more recently, in people affected with multi-infarct dementia. Pyroglutamate administration brought about a significant increase in short and long term memory and an improvement on psychological tests. A statistically significant improvement was observed also in the consolidation of memory. In human subjects, pyroglutamate was compared with placebo in a randomized double-blind trial for assessing its efficacy in treating memory deficits in 40 aged subjects. Twenty subjects were treated with pyroglutamate and 20 with placebo over a period of 60 days. Memory functions were evaluated at baseline
